Nasal SprayFrom $166/mo
InjectionFrom $166/mo
Medically reviewed by Vanessa Niles, R.N., M.D., F.A.C.O.G. —
The short answer
Use the number of sprays your provider prescribes, on the schedule they set. Each spray delivers a fixed amount; your pharmacy label tells you how much NAD+ that is. There's no FDA-approved nasal dose, and human studies of intranasal NAD+ are lacking.
- Sprays per day are set by your provider.
- mg per spray = strength (mg/mL) × volume per spray (mL).
- Prime the pump before first use.
- A hard sniff sends the spray down your throat; breathe gently.
Reading your label
Your label lists the strength in mg per mL and how much each spray delivers. Multiply them to get mg per spray, then by sprays per day for the daily total. If anything is unclear, ask your pharmacist.
NADMedics nasal spray is 30 mg per 0.1 mL in a 15 mL bottle, 4,500 mg of NAD+ in all. If your pump delivers 0.1 mL per spray, each spray contains 30 mg, and a full bottle holds about 150 sprays.
Getting each spray right
MedlinePlus suggests blowing your nose gently before a spray. Prime a new pump by spraying into the air until a fine mist appears, tip your head slightly forward, spray into one nostril and breathe gently so the mist stays in your nose.
Spray math
From label to milligrams
Strength times spray volume gives milligrams per spray. Your provider sets how many sprays.
What the research covers
We found no published human trials of intranasal NAD+; a 2026 study tested it in lab cells and mice. That's why your provider adjusts the dose based on how you feel, not a published target.
NAD+ terms used in this guide
Questions
Questions people also ask
One nostril or both?
Follow your label. Many plans alternate nostrils to reduce irritation.
Can I use more sprays if I don't feel anything?
Not without your provider's okay.
What if it burns?
A brief sting is common at first. Tell your provider if it doesn't settle.
How many sprays are in a bottle?
If your pump delivers 0.1 mL per spray, a 15 mL bottle holds about 150 sprays, minus a few used to prime the pump.
What time of day should I use it?
Follow your provider's schedule. If evening doses keep you awake, ask about using it in the morning.
What if I sneeze right after a spray?
Don't repeat the dose unless your provider tells you to. Breathing in gently helps the mist stay in your nose.
Keep reading
Related NAD+ guides
- NAD+ Nasal Spray Effectiveness: Does It Really Work Well?Does NAD+ nasal spray work? See what research shows about intranasal NAD+, why human trials are missing and how to judge whether it's worth trying.NAD+ nasal spray
- NAD+ Nasal Spray vs Injection: Which Delivery Method Wins?NAD+ nasal spray or injection? Compare how each is used, side effects, needles, convenience and evidence, and see why neither has been proven better.NAD+ nasal spray
- Does NAD+ Nasal Spray Need to Be Refrigerated? A Quick GuideDoes NAD+ nasal spray need refrigeration? Follow your pharmacy label. Learn general storage tips, travel advice and what to do if a spray gets warm.NAD+ nasal spray
Official sources
Sources and official resources
Official government and research sources behind this page, so you can check the facts yourself.
- MedlinePlus (National Library of Medicine)How to Use Nasal Sprays
General steps for using a nasal spray correctly.
- Experimental & Molecular MedicineYoo et al. Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction (2026)
Laboratory and mouse study of intranasal NAD+; not a human trial.
- U.S. Food and Drug AdministrationDifferences in strength expression on compounded product labels may lead to dosing errors
Why reading mg per mL correctly matters.
- U.S. Food and Drug AdministrationCompounding and the FDA: Questions and Answers
What compounded medicines are and why they aren't FDA-approved.
- MedlinePlus (National Library of Medicine)Storing your medicines
Heat, air, light and moisture can damage medicines; ask your pharmacist about storage.
Medically reviewed by Dr. Vanessa Niles, R.N., M.D., F.A.C.O.G., on October 12, 2026. This article is general education, not medical advice. NAD+ has no FDA-approved use, and compounded NAD+ is not FDA-approved or evaluated by the FDA for safety or effectiveness. Only your provider can set your dose.
Talk it through with a provider
Book a free online consultation. If NAD+ fits, a licensed U.S. provider prescribes the nasal spray or injection, with plans from $166 a month.
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