Nasal SprayFrom $166/mo
InjectionFrom $166/moParkinson's disease
In the NADPARK trial, 30 people with Parkinson's took oral NR for 30 days. Brain NAD rose and NR was well tolerated; larger trials are needed to know if it helps symptoms.
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Research, not approved treatments
NAD+ and Health Conditions
NAD+ isn't approved to treat any condition. Here's where it's being studied, what the early results are, and the situations where NADMedics providers won't prescribe it.
Medically reviewed by Vanessa Niles, R.N., M.D., F.A.C.O.G. —
Being studied
Conditions in NAD+ research
Most of these trials used precursors taken by mouth, not the NAD+ injections or spray we offer.
Heart failure
In people with heart failure with reduced ejection fraction, oral NR roughly doubled whole-blood NAD+ and appeared safe. Effects on heart function weren't established.
Prediabetes
Ten weeks of oral NMN increased muscle insulin sensitivity by about 25% in women with prediabetes, per an NIH summary. It didn't test diabetes prevention.
Age-related muscle decline
Oral NMN raised blood NAD in older men and middle-aged adults, with nominal or modest changes in walking and grip measures. Results are early.
Chronic fatigue syndrome
In a crossover trial of oral NADH, 8 of 26 people responded compared with 2 of 26 on placebo. The study was small and hasn't settled the question.
Loss of smell
A 2026 study tested intranasal NAD+ in human olfactory stem cells and mice with smell loss. There are no human trials yet.
Keep perspective
Studied isn't the same as proven
A small, short trial can show a molecule is safe enough to study further, or that it changes a lab marker. It takes larger trials to show it improves a condition.
A 2020 benefit/risk review of NAD+ therapy called for exactly that: more long-term human research. See our benefits page for what the evidence supports today.
When NADMedics won’t prescribe NAD+
- Pregnancy or breastfeeding, since safety hasn't been studied
- Anyone under 18
- Active cancer treatment, unless your oncologist agrees
- Anyone who can't safely give themselves injections (for the injection)
- Serious medical conditions a provider believes make it unsuitable
Conditions to discuss with your provider
These don’t automatically rule NAD+ out, but your provider needs to know:
- Liver or kidney disease
- Heart disease, or chest symptoms with past doses
- Many prescription medicines or supplements
- A history of cancer
Questions
NAD+ and conditions: common questions
Can NAD+ treat my condition?
NAD+ isn't FDA-approved to treat any condition. Research is early, and it shouldn't replace treatment from your doctor.
Should I stop my current treatment to try NAD+?
No. Never stop or change a prescribed treatment without your doctor. Tell your NADMedics provider about every condition and medicine.
Why do studies use NR and NMN instead of NAD+?
They're precursors the body turns into NAD+ and are easy to take by mouth. Trials of NAD+ injections or spray are very limited.
Can NAD+ help with addiction recovery?
NAD+ isn't FDA-approved for this or any use, and it should never replace medical treatment for substance use. SAMHSA's National Helpline (1-800-662-4357) offers free, confidential support 24/7.
Is NAD+ safe with diabetes medicines?
Interactions haven't been well studied. Tell your provider about every medicine you take, including diabetes medicines.
Can I use NAD+ if I've had cancer?
Discuss it with your provider and your oncologist first. NADMedics doesn't prescribe NAD+ during active cancer treatment without the oncologist's agreement.
Keep learning
Related NAD+ guides
- Are NAD+ Injections Safe? The Real Risks and Benefits SharedAre NAD+ injections safe? See the common side effects, what FDA alerts found about contaminated NAD+, who should avoid it and how to lower your risk.NAD+ injections · 6 min read
- NAD Nasal Spray vs Pill: Which Option Truly Works Better?NAD+ nasal spray vs pills: compare oral NAD+, NADH, NR and NMN with prescription spray, what human trials show for each and the costs and trade-offs.NAD+ nasal spray · 5 min read
- How Long Should You Take NAD+ Injections? A Usage Guide NowHow long should you take NAD+ injections? There's no long-term data, so plans are reviewed regularly. Learn when to reassess, pause or stop with your provider.NAD+ injections · 4 min read
Official sources
NAD+ and conditions: sources and research
Official government and research sources behind this page, so you can check the facts yourself.
- NIH PubMedBrakedal et al. The NADPARK study: nicotinamide riboside in Parkinson's disease (2022)
Phase I trial: oral NR raised brain NAD levels and was well tolerated.
- NIH PubMedWang et al. Safety and tolerability of nicotinamide riboside in heart failure with reduced ejection fraction (2022)
Pilot trial: NR roughly doubled whole-blood NAD+ and appeared safe.
- NIH PubMedYoshino et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women (2021)
10-week randomized trial of oral NMN.
- National Institutes of HealthSupplement improves glucose metabolism in women's muscle
NIH summary of the 2021 NMN trial in women with prediabetes.
- npj AgingIgarashi et al. Chronic NMN supplementation elevates blood NAD and alters muscle function in healthy older men (2022)
12-week trial of 250 mg/day oral NMN in men 65 and older.
- GeroScienceYi et al. The efficacy and safety of NMN supplementation in healthy middle-aged adults (2023)
60-day randomized trial of 300, 600 and 900 mg/day oral NMN.
- NIH PubMedForsyth et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome (1999)
Small placebo-controlled crossover trial of oral NADH.
- Experimental & Molecular MedicineYoo et al. Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction (2026)
Laboratory and mouse study of intranasal NAD+; not a human trial.
- NIH PubMedNAD+ therapy in age-related degenerative disorders: a benefit/risk analysis (2020)
Weighs early promise against the lack of long-term human trials.
- U.S. Food and Drug AdministrationCompounding and the FDA: Questions and Answers
What compounded medicines are and why they aren't FDA-approved.
Medically reviewed by Dr. Vanessa Niles, R.N., M.D., F.A.C.O.G., on October 12, 2026. This page summarizes research and is not medical advice. NAD+ has no FDA-approved use and is not a treatment for any disease.
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