Nasal SprayFrom $166/mo
InjectionFrom $166/mo
Medically reviewed by Vanessa Niles, R.N., M.D., F.A.C.O.G. —
The short answer
There's no evidence-based course length. Because long-term safety and benefit haven't been studied, it makes sense to review your plan with your provider at regular check-ins and decide together whether to continue, adjust or stop.
- No study has followed NAD+ injection users long term.
- Set check-in points with your provider from the start.
- Stop if side effects outweigh what you notice.
- Pausing is an option; talk it through with your provider.
What the evidence covers
Human studies of NAD+ and its precursors have mostly lasted days to a few months: six hours of IV NAD+, six weeks of NR, 10 to 12 weeks of NMN. A 2020 benefit/risk review stressed the lack of long-term human trials.
Questions for each check-in
- What, if anything, have I noticed?
- Have side effects changed?
- Have my health, medicines or goals changed?
- Is this still worth the cost and effort?
Over time
Check in, then decide
Think of NAD+ as a plan you revisit, not a program you're locked into.
NAD+ terms used in this guide
Questions
Questions people also ask
Will benefits disappear if I stop?
There's no long-term data to say. Talk to your provider before stopping so you can plan together.
Do I need to taper off?
NAD+ isn't known to need a taper, but follow your provider's advice.
Can I cancel my NADMedics plan anytime?
Yes. There's no contract or cancellation fee.
How often will I check in with my provider?
Your provider sets check-ins. Use them to review side effects, what you've noticed and whether to continue.
What happens when my supply runs out?
Contact your care team before you run out so they can plan your next order, if you're continuing.
Can I restart after stopping?
Yes. Talk to your provider so they can review your health and restart safely.
Keep reading
Related NAD+ guides
- How Often Should You Get NAD Injections? A Quick Time GuideHow often should you get NAD+ injections? Learn why schedules vary, what shapes how often your provider has you inject and why more often isn't always better.NAD+ injections
- Are NAD+ Injections Safe? The Real Risks and Benefits SharedAre NAD+ injections safe? See the common side effects, what FDA alerts found about contaminated NAD+, who should avoid it and how to lower your risk.NAD+ injections
- Does Insurance Cover NAD Injections? What You Need to KnowDoes insurance cover NAD+ injections? Usually not. See why compounded NAD+ is rarely covered, what Medicare rules say and whether an HSA or FSA may help.Getting started
Official sources
Sources and official resources
Official government and research sources behind this page, so you can check the facts yourself.
- NIH PubMedNAD+ therapy in age-related degenerative disorders: a benefit/risk analysis (2020)
Weighs early promise against the lack of long-term human trials.
- Frontiers in Aging NeuroscienceGrant et al. Changes in the human NAD+ metabolome during a 6-hour NAD+ infusion (2019)
Small pilot study of intravenous NAD+ in healthy adults.
- NIH PubMed CentralMartens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults (2018)
Randomized crossover trial of oral NR in healthy adults.
- NIH PubMedYoshino et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women (2021)
10-week randomized trial of oral NMN.
- npj AgingIgarashi et al. Chronic NMN supplementation elevates blood NAD and alters muscle function in healthy older men (2022)
12-week trial of 250 mg/day oral NMN in men 65 and older.
Medically reviewed by Dr. Vanessa Niles, R.N., M.D., F.A.C.O.G., on October 12, 2026. This article is general education, not medical advice. NAD+ has no FDA-approved use, and compounded NAD+ is not FDA-approved or evaluated by the FDA for safety or effectiveness. Only your provider can set your dose.
Talk it through with a provider
Book a free online consultation. If NAD+ fits, a licensed U.S. provider prescribes the nasal spray or injection, with plans from $166 a month.
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