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NAD+ glossary · Treatment & safety

What is a subcutaneous injection?

A subcutaneous injection is a shot into the fatty layer just under the skin, usually in the belly or thigh, with a short, thin needle. It's how at-home NAD+ injections are given.

  • Also calledSQ, sub-Q
  • CategoryTreatment & safety
  • Term26 of 30

Medically reviewed by Vanessa Niles, R.N., M.D., F.A.C.O.G. —

Definition

Subcutaneous injection, in plain English

MedlinePlus explains that a subcutaneous (SQ or sub-Q) injection is given in the fatty tissue just under the skin. The National Cancer Institute defines subcutaneous simply as 'beneath the skin.'

Medicine absorbs more slowly than it would from a vein, and the technique is simple enough to learn at home. MedlinePlus advises changing the injection site each time, at least an inch from the last one.

Goes into
Fat layer under the skin
Common sites
Belly, thigh
Also called
SQ, sub-Q
Cross-section of skin layers showing a short needle delivering medicine into the fat layer beneath the skin
A subcutaneous shot goes into the fat layer, not the muscle or a vein.

How it connects

Subcutaneous NAD+ has very little published research compared with IV NAD+. Your provider sets the dose and schedule and shows you the technique.

Browse all 30 NAD+ terms

For your treatment

What subcutaneous injection means for NAD+ therapy

Put used needles straight into a sharps container and follow the FDA's disposal guidance. Never flush them or throw them loose in the trash.

  • Free online consultation with a licensed U.S. provider
  • NAD+ nasal spray or injection, plans from $166 a month if prescribed
  • NAD+ has no FDA-approved use; compounded NAD+ isn’t FDA-approved

Questions

Subcutaneous injection: common questions

What is a subcutaneous injection?

A subcutaneous injection is a shot into the fatty layer just under the skin, usually in the belly or thigh, with a short, thin needle. It's how at-home NAD+ injections are given.

Does a subcutaneous injection hurt?

Most people feel a quick pinch. A small needle and a slow, steady push usually make it more comfortable.

Where do I inject NAD+?

Usually the belly or thigh, as your provider shows you. Rotate sites each time.

What strengths does NADMedics prescribe?

Nasal spray: 30 mg per 0.1 mL in a 15 mL bottle. Injection: 200 mg/mL in a 5 mL vial. Your provider sets your dose.

How do I report a side effect?

Tell your provider, and you can report it to the FDA's MedWatch program. Call 911 for chest pain or trouble breathing.

Do I need a prescription for NAD+?

Yes. Compounded NAD+ requires a prescription from a licensed provider after a review of your health.

Official sources

Subcutaneous injection: sources and official resources

Official government and research sources behind this page, so you can check the facts yourself.

  1. MedlinePlus (National Library of Medicine)Subcutaneous (SQ) injections

    Step-by-step guide to giving a shot into the fatty tissue under the skin.

  2. National Cancer InstituteNCI Dictionary of Cancer Terms: subcutaneous

    Subcutaneous means beneath the skin.

  3. U.S. Food and Drug AdministrationSafely Using Sharps (Needles and Syringes) at Home, at Work and on Travel

    How to store and throw away used needles and syringes safely.

  4. U.S. Food and Drug AdministrationDisposal of Unused Medicines: What You Should Know

    Take-back locations and safe ways to get rid of medicine you no longer need.

Medically reviewed by Dr. Vanessa Niles, R.N., M.D., F.A.C.O.G., on October 12, 2026. This glossary is general education, not medical advice. NAD+ has no FDA-approved use, and compounded NAD+ is not FDA-approved or evaluated by the FDA for safety or effectiveness. Talk with a licensed provider before starting any supplement or treatment.

Questions about NAD+? Ask a provider

Book a free online consultation. A licensed U.S. provider reviews your health and, if NAD+ fits, prescribes the nasal spray or injection, with plans from $166 a month.

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